Advancing Science for Prader-Willi Syndrome (PWS) Patients and Families

Levo Therapeutics has a singular focus – understanding the pathophysiology of Prader-Willi syndrome to advance treatments that will make a difference in the lives of patients and their families.

Exploring a Potential New Prader-Willi Syndrome Treatment

A Phase 3 trial investigating LV-101 (intranasal carbetocin) in Prader-Willi syndrome will be starting later this year. Learn more about the trial here (coming soon).

Looking to the Future of Prader-Willi Syndrome Treatment

Our lead candidate is LV-101 (intranasal carbetocin). We also are working to develop an earlier stage pipeline that builds on the emerging science of metabolic hormone regulation and gene activation in Prader-Willi syndrome.

PWS: A False State of Starvation

Prader-Willi syndrome is complex and presents a unique set of challenges reflecting a false state of starvation.  This includes anxiety, compulsivity, life-threatening hyperphagia, mild to moderate levels of intellectual disability, growth hormone deficiency, and a high risk of obesity. Occurring in approximately 1 in 16,000 births, the underlying cause of Prader-Willi syndrome is the lack of expression of paternally inherited genes on a small part of chromosome 15.